Prenatal exposure to maternal psychosocial stress and HPA axis regulation in young adults.
Identifieur interne : 000D95 ( Main/Exploration ); précédent : 000D94; suivant : 000D96Prenatal exposure to maternal psychosocial stress and HPA axis regulation in young adults.
Auteurs : Sonja Entringer [Allemagne] ; Robert Kumsta ; Dirk H. Hellhammer ; Pathik D. Wadhwa ; Stefan WüstSource :
- Hormones and behavior [ 1095-6867 ] ; 2009.
English descriptors
- KwdEn :
- Adrenocorticotropic Hormone (blood), Adult, Birth Weight, Carrier Proteins (metabolism), Female, Humans, Hydrocortisone (blood), Hydrocortisone (metabolism), Hypothalamo-Hypophyseal System (physiology), Male, Neuropsychological Tests, Pituitary-Adrenal System (physiology), Pregnancy, Prenatal Exposure Delayed Effects, Saliva (metabolism), Sex Factors, Stress, Psychological (physiopathology), Surveys and Questionnaires, Young Adult.
- MESH :
- chemical , blood : Adrenocorticotropic Hormone, Hydrocortisone.
- chemical , metabolism : Carrier Proteins, Hydrocortisone.
- metabolism : Saliva.
- physiology : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System.
- physiopathology : Stress, Psychological.
- Adult, Birth Weight, Female, Humans, Male, Neuropsychological Tests, Pregnancy, Prenatal Exposure Delayed Effects, Sex Factors, Surveys and Questionnaires, Young Adult.
Abstract
Epidemiological studies have reported associations between measures of size and weight at birth and disease risk in later life. Alteration in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis in response to prenatal stress has been proposed as one underlying mechanism. The present study investigated in humans the association of prenatal psychosocial stress exposure with subsequent HPA axis regulation in adult life, with a focus on measures of response to challenge and feedback sensitivity. Healthy young adults whose mothers experienced severe stress during their pregnancy in form of major negative life events (e.g. death of someone close; prenatal stress (PS) group, n=31) and an age-matched comparison group (CG, n=30) underwent the Trier Social Stress Test (TSST) and a 1 microg ACTH(1-24) stimulation test. In addition, a diurnal cortisol profile was assessed. ACTH concentrations following a standardized behavioural challenge paradigm (TSST) were marginally significantly higher in PS subjects than in CG subjects (p=.06). Pre-TSST adrenocortical (cortisol) levels were lower (p=.007), whereas the increase in cortisol in response to the TSST was higher (p=.03) in PS subjects compared to CG subjects. Cortisol concentrations following a pharmacological stimulation test simulating pituitary activity (ACTH(1-24) test) were significantly lower in PS than in CG subjects (p=.006). No differences emerged between the two groups in basal diurnal cortisol levels. This study provides first evidence in humans of an association between prenatal psychosocial stress exposure and subsequent alterations in the regulation of the HPA axis.
DOI: 10.1016/j.yhbeh.2008.11.006
PubMed: 19084531
Affiliations:
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Hellhammer</name></author><author><name sortKey="Wadhwa, Pathik D" sort="Wadhwa, Pathik D" uniqKey="Wadhwa P" first="Pathik D" last="Wadhwa">Pathik D. Wadhwa</name></author><author><name sortKey="Wust, Stefan" sort="Wust, Stefan" uniqKey="Wust S" first="Stefan" last="Wüst">Stefan Wüst</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19084531</idno><idno type="pmid">19084531</idno><idno type="doi">10.1016/j.yhbeh.2008.11.006</idno><idno type="wicri:Area/PubMed/Corpus">000594</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000594</idno><idno type="wicri:Area/PubMed/Curation">000594</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000594</idno><idno type="wicri:Area/PubMed/Checkpoint">000594</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000594</idno><idno type="wicri:Area/Ncbi/Merge">000345</idno><idno type="wicri:Area/Ncbi/Curation">000345</idno><idno type="wicri:Area/Ncbi/Checkpoint">000345</idno><idno type="wicri:Area/Main/Merge">000E67</idno><idno type="wicri:Area/Main/Curation">000D95</idno><idno type="wicri:Area/Main/Exploration">000D95</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Prenatal exposure to maternal psychosocial stress and HPA axis regulation in young adults.</title><author><name sortKey="Entringer, Sonja" sort="Entringer, Sonja" uniqKey="Entringer S" first="Sonja" last="Entringer">Sonja Entringer</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical and Physiological Psychology, University of Trier, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Clinical and Physiological Psychology, University of Trier, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Kumsta, Robert" sort="Kumsta, Robert" uniqKey="Kumsta R" first="Robert" last="Kumsta">Robert Kumsta</name></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name></author><author><name sortKey="Wadhwa, Pathik D" sort="Wadhwa, Pathik D" uniqKey="Wadhwa P" first="Pathik D" last="Wadhwa">Pathik D. Wadhwa</name></author><author><name sortKey="Wust, Stefan" sort="Wust, Stefan" uniqKey="Wust S" first="Stefan" last="Wüst">Stefan Wüst</name></author></analytic><series><title level="j">Hormones and behavior</title><idno type="eISSN">1095-6867</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenocorticotropic Hormone (blood)</term><term>Adult</term><term>Birth Weight</term><term>Carrier Proteins (metabolism)</term><term>Female</term><term>Humans</term><term>Hydrocortisone (blood)</term><term>Hydrocortisone (metabolism)</term><term>Hypothalamo-Hypophyseal System (physiology)</term><term>Male</term><term>Neuropsychological Tests</term><term>Pituitary-Adrenal System (physiology)</term><term>Pregnancy</term><term>Prenatal Exposure Delayed Effects</term><term>Saliva (metabolism)</term><term>Sex Factors</term><term>Stress, Psychological (physiopathology)</term><term>Surveys and Questionnaires</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Adrenocorticotropic Hormone</term><term>Hydrocortisone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Carrier Proteins</term><term>Hydrocortisone</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Stress, Psychological</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Birth Weight</term><term>Female</term><term>Humans</term><term>Male</term><term>Neuropsychological Tests</term><term>Pregnancy</term><term>Prenatal Exposure Delayed Effects</term><term>Sex Factors</term><term>Surveys and Questionnaires</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Epidemiological studies have reported associations between measures of size and weight at birth and disease risk in later life. Alteration in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis in response to prenatal stress has been proposed as one underlying mechanism. The present study investigated in humans the association of prenatal psychosocial stress exposure with subsequent HPA axis regulation in adult life, with a focus on measures of response to challenge and feedback sensitivity. Healthy young adults whose mothers experienced severe stress during their pregnancy in form of major negative life events (e.g. death of someone close; prenatal stress (PS) group, n=31) and an age-matched comparison group (CG, n=30) underwent the Trier Social Stress Test (TSST) and a 1 microg ACTH(1-24) stimulation test. In addition, a diurnal cortisol profile was assessed. ACTH concentrations following a standardized behavioural challenge paradigm (TSST) were marginally significantly higher in PS subjects than in CG subjects (p=.06). Pre-TSST adrenocortical (cortisol) levels were lower (p=.007), whereas the increase in cortisol in response to the TSST was higher (p=.03) in PS subjects compared to CG subjects. Cortisol concentrations following a pharmacological stimulation test simulating pituitary activity (ACTH(1-24) test) were significantly lower in PS than in CG subjects (p=.006). No differences emerged between the two groups in basal diurnal cortisol levels. This study provides first evidence in humans of an association between prenatal psychosocial stress exposure and subsequent alterations in the regulation of the HPA axis.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Rhénanie-Palatinat</li></region><settlement><li>Trèves (Allemagne)</li></settlement><orgName><li>Université de Trèves</li></orgName></list><tree><noCountry><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name><name sortKey="Kumsta, Robert" sort="Kumsta, Robert" uniqKey="Kumsta R" first="Robert" last="Kumsta">Robert Kumsta</name><name sortKey="Wadhwa, Pathik D" sort="Wadhwa, Pathik D" uniqKey="Wadhwa P" first="Pathik D" last="Wadhwa">Pathik D. Wadhwa</name><name sortKey="Wust, Stefan" sort="Wust, Stefan" uniqKey="Wust S" first="Stefan" last="Wüst">Stefan Wüst</name></noCountry><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Entringer, Sonja" sort="Entringer, Sonja" uniqKey="Entringer S" first="Sonja" last="Entringer">Sonja Entringer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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